Science as a Game Changer

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Endovelico
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Science as a Game Changer

Post by Endovelico »

I created this new thread here on Current Events, because this goes way beyond science.
Catastrophic Success
By Pat Cox, Editor

Breakthrough Technology Alert

When the second stimulus bill passed in February, 2009, I explained to my readers that the "crowding out effect" would guarantee its failure. I took no pleasure in predicting accurately that increased government borrowing would crowd out private investment in innovation, from which flows economic and employment growth.

I bring this up simply because I have extraordinarily good news regarding cancer therapeutics, and I don't want you to assume that I am afflicted with blind optimism. For decades, in fact, I've been among the economists who have warned that our current distress was coming. As you know, we were ignored by the intelligentsia. As a result, the entirely avoidable mortgage and housing bubbles expanded and collapsed, which accelerated our even larger problem – the entitlements crisis.

Political corruption and malfeasance were involved, we now know. I suspect, however, that the larger reason the warnings signs were ignored was essentially psychological. Most people avoid extremely unpleasant news until they no longer have a choice.

This is particularly true with regards to the entitlement crisis because it involves perhaps the greatest unpleasantness of all. It is the reality that we are all facing the prospect of aging, serious illness, and death – in that order.

The aging population, however, is the root cause of our financial problems. More than a third of the federal budget goes to transfer payments and services for people age 65 or older. Nevertheless, we're behind on the payments and the bill is increasing as more and more people live longer.

This is the result, primarily, of unexpected scientific breakthroughs that have dramatically expanded our medical options. Unfortunately, Social Security was designed in 1935, when fewer lived to see the retirement age of 65. Only a fringe of visionaries believed that new technologies would push life spans close to 80 by the end of the century.

Nevertheless, it has happened. Retirement ages, though, have not adjusted, so Social Security is running on empty. Medicare may not have been designed to benefit the aged, but about half of all healthcare services are consumed by the five percent of the population that is dying. They are, it's no wonder, almost all older people.

These worsening fundamentals have not plateaued. The demographic pyramid, with large numbers of young payers and very few aged beneficiaries, is flipping. I'm sorry to be the bearer of bad news, but I hope at least to convince you that I'm not in denial about the problems we face. Therefore, I hope you'll take me seriously when I say that very recent scientific breakthroughs are more than capable of solving our entitlement and debt crises.

The End of Cancer as a Deadly Threat

Last week, an announcement was made by BioTime Inc. that could quickly cut the cost of cancer in half, saving in excess of $100 billion annually. This breakthrough is not a cancer treatment. It is a revolutionary diagnostic technology.

To understand why it is so important, we need to understand that cancer isn't a single disease at all. The medical term is "malignant neoplasm," which encompasses any condition of uncontrolled cell growth. There are hundreds if not thousands of different types of malignant neoplasms, and many have almost nothing in common with any of the others.

This has made cancer diagnostics very inefficient, though it is a multi-billion-dollar industry. A test for prostate cancer, for example, won't detect breast cancer. Even current breast cancer tests don't detect all breast cancers.

If all the existing diagnostics were used to test one individual for early-stage cancers, it would cost many tens of thousands of dollars – perhaps more. If all people were checked for all cancers on a regular basis using existing diagnostics, it would bankrupt our entire healthcare system.

To make matters even worse, many diagnostics are notoriously inaccurate. Some miss as many as half of cancers but return extremely high false positives that have their own costs. False-positive PSA (prostate-specific antigen) tests, for example, generate unnecessary biopsies, surgery, impotence, incontinence, and other problems. Some diagnostic procedures, I might add, are also extremely unpleasant.

As a result, most people are tested for cancers only when there is reason to believe they may have the disease. Most diagnostics are used, therefore, to gain information about existing and problematic cancers, not to detect them before they become a problem.

As a result, many cancers are not found until they are sadly well-established and aggressive. It is an oft-repeated truism in oncology that early detection translates into far more successful treatment. Early detection also dramatically reduces the costs of therapy.

What we need, obviously, is a simple blood test that would, with high accuracy, find cancers in their early stages. Combined with revolutionary new cancer therapies that are just around the corner, we would see the end of most catastrophic cancers. Even with existing therapies, the impact on lives and healthcare budgets would be enormous.
Moore's Law, Bioinformatics, and Genomics

Over the last few years, I've written often about BioTime's ACTCellerate program, one of the most important projects in contemporary science. Dr. Michael West and BioTime scientists are decoding and cataloging the genetic changes that occur in human cells as they progress from their original embryonic state.

To accomplish this monumental task, BioTime scientists rely on large-scale genomic analysis and bioinformatic analysis of the data, using increasingly powerful computers. Thus far, BioTime scientists have mapped over 40,000 gene sequences expressed in different cell types.

This information will allow BioTime to turn a few of your blood cells into induced pluripotent cells, and then into any type of cell you need. Those cells will be completely rejuvenated and functionally young. Already, BioTime's ReCyte Group is on track to reverse age-related cardiovascular and immune-system conditions.

However, the knowledge and tools that the company has created have far more uses than hacking cellular codes. BioTime used the same tools to examine hundreds of adult cell types, both normal and cancerous. In the process, they discovered that many genes being activated in cancers had never before been associated with malignant neoplasms.

Genes express proteins that can be easily detected. (A simple consumer version of a protein detector, by the way, is the home pregnancy test.) And having identified the genes activated by the most-common cancers, it was a relatively simple process for BioTime to design a blood test for the proteins expressed by those genes.

This is off-the-shelf technology. Many medical device companies manufacture diagnostic devices that identify proteins in blood. But early in-house tests found that BioTime's prototype was more accurate in terms of identifying cancer-free individuals than is commonly observed in PSA cancer tests. This discovery convinced the company to prioritize development of the technology.

BioTime's commercial cancer-detection device will probably be priced no higher than existing diagnostics that test for only one type of cancer. I expect the device will detect a wide range of cancer types, including cancers of the breast, lung, bladder, uterus, stomach, and colon, as well as others.

My guess, looking at wholesale prices for similar laboratory devices, is that the cost in materials for testing an individual for a broad spectrum of the most-common cancers will eventually be no more than $15. It is impossible to predict the size of the market for a simple broad-spectrum cancer detection test, because no such diagnostic exists; but the potential is huge.

The von Eschenbach Connection

This is a true disruptive technology and its impact will be noticeable both in terms of average life expectancy and healthcare costs. The announcement explains why, several months ago, Andrew von Eschenbach, Ph.D., joined the board of BioTime.

I've long considered BioTime the leader in the field of regenerative medicine. I was nevertheless puzzled when von Eschenbach joined the team. His resumŽ includes former jobs such as commissioner of the FDA during George W. Bush's term and director of the National Cancer Institute. He is considered by many to be the leader in the fight against cancer. In 2003, when he was director of the National Cancer Institute, von Eschenbach announced his goal of eliminating suffering and death due to cancer by 2015.

His motive for working with BioTime is now obvious. I've spoken to him since then, and he's confirmed that he believes the BioTime pan-cancer diagnostic will have an enormous impact as soon as it is widely implemented. Moreover, he believes subsequent applications of the technology have the potential to deliver true personalized medicine with extremely effective therapies specifically tailored for individual patients.

Von Eschenbach's goal of reducing cancer to an irritation rather than a killer is achievable – even if his time frame was off. It might not be that inaccurate, however, as BioTime has chosen to go first for European approval of the CE marking process . As approval of devices in Europe is much faster than it is the US, we could see the test on the market there before the end of 2014. Many countries outside of Europe take their lead from the EU, so it should move rapidly into Canada and other markets. With post-market data from these nations, I would expect that approval in the US would take as little as one additional year.

Then, because early detection of the most common cancers would be simple and inexpensive, insurance companies would find it in their own financial interest to encourage routine PanC-Dx testing, as BioTime is calling their technology. Because physicians are already familiar with this type of testing, market penetration will not require overcoming a learning curve. Cancer rates and costs will begin to fall dramatically.

That, however, is only the beginning of the story. Simultaneously, a raft of next-generation cancer therapies will be coming to market.

Though I've already tested your attention span, I'd really like to give you just a brief overview of some of the most exciting new drugs coming to oncology. These are drugs so far beyond anything you've seen yet, they make current treatments seem medieval by comparison.

Bexion Therapeutics

Bexion, while still private, has attracted enormous attention where it matters. Their drug consists of a nanotech joining of two naturally occurring substances found in human cells. Together, they have the ability to exploit one of the few characteristics that all cancer cell share, the transfer of phosphatidylserines to cell wall exteriors to fend off immune response.

When the Bexion drug is administered, these nano-probes seek out phosphatidylserines and collect on the surface of cancer cells. There they trigger natural cell suicide, or apoptosis. Cancers die but healthy cells are unharmed.

Bexion's drug has been shown effective in preclinical tests against an extraordinary range of cancers. Moreover, its seek-and-destroy mechanism could make it an ideal diagnostic tool for use in conjunction with BioTime's broad-spectrum blood test. Because a marker can be attached to the Bexion drug, it is possible to light up cancers using scanning technology, giving doctors a 3D view of neoplasms.

Most remarkably, in animals testing, Bexion's drug appears to somehow bypass the blood-brain barrier. This makes it a most promising candidate for treatment of brain cancers, which are among the most lethal of cancer types. Clinical tests are expected to begin in 2012.

[http://www.bexionpharma.com/]

Provectus Pharmaceuticals

Rose Bengal is an amazing molecule first used in the 1800s as a wool dye. Then it was employed as a diagnostic marker due to its unique ability to penetrate diseased or damaged cells but not healthy cells. In World War II it was used widely and successfully to protect soldiers from malaria, though it was never popular because it turned the whites of users' eyes blue.

In post-war Japan it was used as a food dye, and researchers discovered that humans and animals that consumed the most had the lowest cancer rates. Fast-forward to the Oak Ridge National Laboratory, where scientists were fascinated by the molecule's remarkable electronic characteristics, as well as its ability to absorb and convert light and other low-level radiation.

Extensive "compassionate usage" of a modified Rose Bengal molecule has shown remarkable efficacy in the treatment of metastatic melanoma. Phase II human clinical tests for liver cancer have been completed, with spectacular results. Preclinical indications show similar promise for other organs. Like Bexion's drug, these modified Rose Bengal molecules are dangerous only to cancer cells. I could go on.

Inovio Pharmaceuticals

Inovio is a leader in DNA vaccines. Using an extremely small electrical pulse, the company puts engineered DNA plasmids into cells. These circular rings of DNA utilize the body's own genetic mechanisms to manufacture RNA proteins that train and mobilize the immune system to attack various diseases, including cancers.

Inovio is in Phase II human tests for both leukemia and cervical displasia. Positive results in HIV and hepatitis-C show the adaptability of this technology for treatment of a wide range of diseases.

Galectin Therapeutics

Building on the work of one of the greatest Russian scientists of all time, Alexander Oparin, Galectin Therapeutics is the leader in an entirely new field of science known as glycoscience, which involves the use of complex carbohydrates – essentially foods – as drugs.

One of the deadly characteristics of cancer tumors is their ability to protect themselves by producing proteins that bind with sugars. These are galectin-3s, and tumors use them to create a lethal cloaking field that allows them to hide from our immune systems.

T cells have evolved to attack disease and pass information back to the thymus so specifically targeted T cells can be manufactured in large numbers. However, when T cells encounter a cancer's lethal galectin net, they are shut down and eventually die.

Galectin Therapeutics' naturally occurring plant sugars have the nearly unbelievable ability to protect and resurrect dying T cells. This makes their nontoxic carbohydrate drug, on its own, effective against cancers in general. In conjunction with cancer vaccines or drugs, however, it magnifies the effectiveness of the therapy to a quite astonishing degree.

Currently, the esteemed Ludwig Institute for Cancer Research, the largest international nonprofit dedicated to conquering cancer, is funding Phase I/II clinical tests of a Galectin Therapeutics carbohydrate drug in conjunction with a melanoma vaccine. Oh, and by the way, this drug also appears to reverse the fibrosis that causes cirrhosis of the liver and subsequent liver cancers.

In Conclusion

John Mauldin recently published a letter here that included the term catastrophic success. The banishment of lethal cancers provides us with an example. It will lengthen lives, reduce healthcare costs, and enrich investors. If, however, we do not come to grips with dramatically extended health spans, it could make our entitlement crisis far worse and eventually lead to complete national collapse.

As a society, we failed to heed the clear warnings regarding Fannie Mae, Freddie Mac, and the mortgage and housing bubbles. Many of our so-called intellectuals are still pretending it didn't happen. Similarly, they are behaving as if the entitlement crisis is not serious.

Imminent cancer diagnostics and therapies, as well as breakthroughs in heart disease, Alzheimer's, liver disease, and more will give us the ability to grow our way out of the current financial mess. All we've got to do is stop pretending that a retirement age set in the 1930s makes an ounce of sense today.

Productive life spans will continue to lengthen and the costs of dying will be pushed back significantly. This will give us a window of opportunity to balance our budget. Then, regenerative medicine will really kick in, growing life spans even more rapidly.

These disruptive innovations will change everything. If exploited wisely, they will enable a period of unprecedented prosperity. If they are used to fund political fantasies, though, things will get much worse.
This is why I'm in favour of increasing retirement age to 70, and eventually beyond.
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Endovelico
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Re: Science as a Game Changer

Post by Endovelico »

Endovelico wrote:
Tinker wrote:The entire framework of basing our culture off of jobs is obsolete. Raising the retirement age doesn't help if there are not enough jobs to go around as it is.

And it's not just the extension of lifespan, but the increases in automated production that are fueling this.

People are living longer, and there are fewer and fewer jobs that need doing.
You can work fewer hours for a longer time. Working six hours a day, five days a week, until one is 70 years old, would give more people a bigger chance of having a job without putting undue strain on social security.
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Endovelico
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Re: Science as a Game Changer

Post by Endovelico »

by monster_gardener » Wed Dec 21, 2011 5:55 pm
Tinker wrote:The entire framework of basing our culture off of jobs is obsolete. Raising the retirement age doesn't help if there are not enough jobs to go around as it is.

And it's not just the extension of lifespan, but the increases in automated production that are fueling this.

People are living longer, and there are fewer and fewer jobs that need doing.
Thank you VERY MUCH, Endovelico & Tinker for the thread and posts.

This is wonderful news, Endo, but IMVHO Tinker is probably correct: not enough jobs or a least good jobs that pay a decent wage and getting worse due to automation and other factors.........

Would be nice if we/US/the World became more Cultured :wink:

http://en.wikipedia.org/wiki/The_Culture#Overview
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